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- E. Lambert, V. Gorantla, J.M. Janjic* “Pharmaceutical
Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery
in Regenerative Medicine” Nanomedicine 2019, accepted : Part
of Special Issue “Nanomedicine in Organ Transplantation
and Regenerative Surgery –Advances, Applications, and
Future Directions” Nanomedicine, November, 2019, Co-Edited by. V.S.
Gorantla and J.M. Janjic
- M Saleem, B Deal, E. Nehl, JM Janjic, JA
Pollock* “Nanomedicine-driven neuropathic pain relief in a rat model is
associated with macrophage polaritry and mast cell activation.” Acta
Neuropathol Commun. 2019. 7, Article number: 108
- M. Herneisey, E.Lambert, A. Kachel, E. Shychuck, J. K.
Drennen III and J.M. Janjic* “Quality by Design Approach
Using Multiple Linear and Logistic Regression Modeling Enables
Microemulsion Scale Up” Molecules 2019, 24(11), 2066; https://doi.org/10.3390/molecules24112066
- M Saleem, AM Stevens, B Deal, L Liu, J Janjic,
JA Pollock* “A New Best Practice for Validating Tail Vein Injections in
Rat with Near-infrared-Labeled Agents.” Journal of visualized
experiments: JoVE 2019 (146), e59295, doi:10.3791/59295
- J. M. Janjic
“Inflammation Targeted Nanomedicine: A perspective on the promise
and potential of biomedical technologies for pain diagnosis and management.”
(Invited Article) Practical Pain Management 2019, Vol (19), Issue 1, pages: 33-35
- E. Lambert, J.M. Janjic* “Multiple Linear Regression
Applied to Predicting Droplet Size of Complex Perfluorocarbon
Nanoemulsions for Biomedical Applications” Pharmaceutical
Development and Technology 2019, 24, 700-710
- M. Herneisey, L. Liu, E. Lambert, N. Schmitz, S.
Loftus, and J.M. Janjic* Development of Theranostic Perfluorocarbon
Nanoemulsions as a Model Non-Opioid Pain Nanomedicine Using a Quality by
Design (QbD) Approach AAPS PharmSciTech 2019, 20: 65. https://doi.org/10.1208/s12249-018-1287-6
- J. M. Janjic* and
V.S. Gorantla* “Novel Nanoimaging Strategies for Noninvasive Graft
Monitoring in Vascularized Composite Allotransplantation” invited
commentary, Current Transplantation Reports 2018, 5 (4), 369-372 https://doi.org/10.1007/s40472-018-0221-x
- J. M.
Janjic*, K. Vasudeva, M. Saleem, L. Liu, S.K. Patel, A. Stevens, J.A.
Pollock* “Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion
delivery to neuroinflammation of the sciatic nerve in Rat” Journal
of Neuroimmunology 2018,http://www.jni-journal.com/article/S0165-5728(18)30012-2/fulltext
(The first Theranostic Pain Nanomedicine)
- J. M. Janjic*
and V. Gorantla “Clinically translatable nanotheranostic platforms
for peripheral nerve regeneration: design with outcome in mind”, Proc.
SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular
Probes for Biomedical Applications X, 1050803 (20 February 2018);
doi: 10.1117/12.2289288; https://doi.org/10.1117/12.2289288
- J. M. Janjic*
and V. Gorantla “Peripheral Nerve Nano-Imaging: Monitoring Treatment and
Regeneration” 2017, AAPS J. Sep;19(5), 1304-1316 (invited
review)
- Herneisey, M., Williams, J., Mirtic, J., Liu, L.,
Potdar, S., Bagia, C., Cavanaugh, J.E., Janjic, J.M.* Development
and characterization of resveratrol nanoemulsions carrying dual-imaging
agents Therapeutic Delivery 2016, 7 (12), 795-808
- BJ Kolber, JM Janjic, JA Pollock, KJ Tidgewell
Summer undergraduate research: A new pipeline for pain clinical practice
and research BMC Medical Education 2016 (1), 16:135
DOI: 10.1186/s12909-016-0648-7
- Janjic, J.M.*,
Berlec, A., Bagia, C., Liu, L.S., Jeric, I., Gach, M., Janjic, B.M.,
Strukelj, B.NIR and MR imaging supported hydrogel based delivery system
for anti-TNF alpha probiotic therapy of IBD (2016) Progress in
Biomedical Optics and Imaging – Proceedings of SPIE, 9723, art.
no. 972309
- Liu, L., Bagia,C., Janjic, J.M.* “The
First Scale up Production of Theranostic Nanoemulsions” Bioresearch
Open Access 2015, 4(1): 218-228. (Invited Paper)
- Patel, S.K., Beaino, W., Anderson, C.J., Janjic,
J.M.* Theranostic Nanoemulsions for Macrophage COX-2 Inhibition in
a Murine Inflammation Model Clinical Immunology 2015,
160, 59-70.
- S.K. Patel and J.M. Janjic* “Macrophage Targeted
Theranostics as Personalized Nanomedicine Strategies for Inflammatory
Diseases” Theranostics 2015,(2), 150
- Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic,
J.M., Pollock, J.A.* “In Vivo and Systems Biology Studies Implicate
IL-18 as a Central Mediator in Chronic Pain” Journal of
Neuroimmunology 2015, 283, 43-49
- Wen, Y., Liu, W., Bagia, C., Zhang,
S., Bai, M., Janjic, J.M., Giannoukakis,
N., Gawalt, E. S., Meng, W.S.* “Antibody-Functionalized Peptidic Membranes
for Neutralization of Allogeneic Skin Antigen-Presenting Cells” Acta
Biomaterialia 2014, 10 (11), 4759-4767
- Jia, N., Zhang, S., Shao, P., Bagia, C., Janjic,
J.M., Ding, Y. and Bai, M.* “Cannabinoid CB2 Receptor as a New
Phototherapy Target for Inhibition of Tumor Growth.” Molecular
Pharmaceutics 2014, 11 (6), 1919–1929
- Janjic,
J.M.*, Shao, P., Zhang, S., Yang, X., Patel, S.K., Bai, M.*
“Perfluorocarbon nanoemulsions with fluorescent, colloidal and magnetic
properties” Biomaterials 2014, 35 (18), 4958-4968
- Mountain, G.A., Jelier, B.J., Bagia, C., Friesen,
C.M., Janjic, J.M. * “Design and formulation of nanoemulsions
using 2-(poly (hexafluoropropylene oxide)) perfluoropropyl benzene in
combination with linear perfluoro (polyethylene glycol dimethyl ether)”Journal
of Fluorine Chemistry 2014, 162, 38–44
- K. Vasudeva, K. Andersen, B. Zeyzus-Johns, T.K.
Hitchens, S.K. Patel, A. Balducci, J.M. Janjic, J. A. Pollock*
“Imaging Neuroinflammation In Vivo in a Neuropathic Pain Rat Model with
Near-Infrared Fluorescence and 19F Magnetic Resonance” PloS one 2014,
9 (2), e90589
- M.J. Patrick¥, J.M. Janjic¥, H.
Teng, M.R. O’Hear, C.W. Brown, J.A. Stokum, B.F. Schmidt, E.T.
Ahrens*, A.S. Waggoner “Intracellular pH measurements using
perfluorocarbon nanoemulsions” Journal of the American Chemical Society
2013, 135 (49), 18445-18457. (¥Co-first authors)
- S.K. Patel, J. Williams, J.M. Janjic* “Cell labeling
for 19F MRI: New and Improved Approach to Perfluorocarbon
Nanoemulsion Design” Biosensors 2013, 3(3), 341-359 (open access)
- S.K. Patel, M.J. Patrick, J.A. Pollock, J.M. Janjic*
“Two-color fluorescent (near-infrared and visible) triphasic
perfluorocarbon nanoemulsions” Journal of Biomedical Optics 2013,
18 (10), 101312,
- J.M. Janjic*, S.K.
Patel, M.J. Patrick, J.A. Pollock, E. DiVito, M. Cascio “Suppressing
inflammation from inside out with novel NIR visible perfluorocarbon
nanotheranostics” (Invited Paper) Progress in Biomedical Optics and
Imaging – Proceedings of SPIE 2013, 8596, art. no.
85960L
- S.K. Patel, Y. Zhang, J.A. Pollock, J.M. Janjic*
“Cyclooxygenase-2 Inhibiting Perfluoropoly (ethylene glycol) ether
Theranostic Nanoemulsions – In Vitro Study” PloS one 2013,
8(2):e55802.
- A. Balducci, Y. Wen, Y. Zhang, B.M. Helfer, T.K.
Hitchens, W.S. Meng, A.K. Wesa, J.M. Janjic*, “A novel probe
for the non-invasive detection of tumor-associated inflammation” Oncoimmunology
2013, 2 (2), e23034
- C.E. O’Hanlon, K.G. Amede, M.R. O’Hear, J.M. Janjic*
“NIR-labeled perfluoropolyether nanoemulsions for drug delivery and
imaging” Journal of Fluorine Chemistry 2012,
137, 27–33
- T.K. Hitchens, Q. Ye, D.F. Eytan, J.M. Janjic,
E.T. Ahrens, C. Ho “19F MRI detection of acute
allograft rejection with in vivo perfluorocarbon labeling of immune cells”
Magnetic Resonance in Medicine 2011, 65, 1144-1153
- D.K.K. Kadayakkara, J.M. Janjic, L.K.
Pusateri, W.B. Young, E.T. Ahrens “In vivo observation of
intracellular oximetry in perfluorocarbon-labeled glioma cells and
chemotherapeutic response in the CNS using fluorine-19 MRI” Magnetic
Resonance in Medicine 2010,
64,1252-1259
- B. Helfer, A. Balducci, A. Nelson, J.M. Janjic,
R.R. Gil, P. Kalinski, J. M. de Vries, E.T. Ahrens, R. Mailliard,
“Functional assessment of human dendritic cells labeled for in vivo 19F
MRI cell tracking” Cytotherapy 2010, 12, 238-250.
- D.K.K. Kadayakkara, P. Beatty, J.M. Janjic, M.
Turner, E. Ahrens, O. Finn “Inflammation driven overexpression of the
hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and
pancreatitis” Pancreas 2010, 39, 510-515
- M. Srinivas, M.S. Turner, J.M. Janjic, P.A.
Morel, D.H. Laidlaw, E.T. Ahrens “In vivo cytometry of antigen specific
T-cells using 19F MRI” Magnetic Resonance in Medicine 2009,
62, 747-753
- J.M.
Janjic, E.T. Ahrens “Fluorine-containing nanospheres for MRI”
Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and
Nanobiotechnology, Sept./Oct. 2009, 1, 492-501, invited by
editors
- J.M. Janjic, M. Srinivas, D.K.K. Kadayakkara, E.T.
Ahrens “Self-delivering nanoemulsions for dual fluorine-19 MRI and
fluorescence detection”, Journal
of American Chemical Society 2008,
130, 2832-2413. (highly cited paper, cited >200 times)
- Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day,
B.W. “Biphenyl C-cyclopropylalkylamides as new scaffolds for
targeting estrogen receptor β” Bioorganic Medicinal Chemistry
Letters 2009, 19, 2404-2408.
- Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day,
B.W.; Xie, W. “New Opportunities for pregnane X receptor (PXR) targeting
in drug development. Lessons from enantio- and species-specific PXR
ligands identified from a discovery library of amino acid analogues” Mini
Reviews Medicinal Chemistry 2007, 7, 617-625
- Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer,
P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day,
B.W. “Microwave-Assisted “Libraries from Libraries” Approach toward the
Synthesis of Allyl- and C-Cyclopropylalkylamides,” Journal of
Combinatorial Chemistry 2005, 7, 322-330.
- Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs,
R.B.; Kroboth, P.D.; Smith, R.B.; “GEAR-UP (Graduate Education And
Research at the University of Pittsburgh), A Program for Educating
Students about Pharmaceutical Research,” American Journal of
Pharmaceutical Education 2005, 69, 91-97. (co-wrote the paper,
co-designed the study, served on the organizational committee of the
program 2001-2004)
- Janjic, J.M.;
Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S.
; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. “New Antiestrogens from a
Library Screen of Homoallylic Amides, Allylic Amides and
C-Cyclopropylalkylamides,” Bioorganic and Medicinal Chemistry 2005,
13, 157-164.
- Wipf, P.; Janjic, J.M.; Stephenson, C.R.
“Microwave-assisted synthesis of allylic amines: considerable rate
acceleration in the hydrozirconation-transmetalation-aldimine addition
sequence,” Organic and Biomolecular Chemistry 2004,
2, 443-445.
- Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside,
T.L.; Storkus, W.J.; Vujanovic, N.L. “Innate direct anticancer effector
function of human immature dendritic cells. II. Role of TNF,
lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related
apoptosis-inducing ligand,” Journal of Immunology 2002,
168, 1831-1839.
Book Chapters
- W.
Meng* and J.M. Janjic Book chapter “Principles of Nanomedicine
” in book titled: Nanomedicine for Inflammatory Diseases edited by Lara
Sheherazade Milane and Mansoor M. Amiji, invited by the editors, 2017 Nanomedicine
for Inflammatory Diseases, 39-66
- J.M.
Janjic* and S.K. Patel
“Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist’s
Perspective” book chapter in book titled: Fluorine Magnetic Resonance
Imaging Edited by Ulrich Flögel & Eric Ahrens, invited by the editors,
Pan Stanford Publishing Pte. Ltd. 2016 DOI:
10.1201/9781315364605-15
- J.M.
Janjic*, S.K. Patel, C. Bagia
“Utilization of Near-Infrared Fluorescent Imaging for Pharmaceutically
Relevant Applications” Book chapter in 2016 In Vivo
Fluorescence Imaging: Methods and Protocols, 97-108, edited by
Mingfeng Bai, PhD, Springer New York 2016 DOI:
10.1007/978-1-4939-3721-9_10, invited by the editors
- J.M.
Janjic and M. Bai “Design and
Development of Theranostic Nanomedicines” Chapter in: Nanotechnology
for Biomedical Imaging and Diagnostics: From Nanoparticle Design to
Clinical Applications, Edited by Mikhail Berezin, John Wiley &
Sons, Inc; 2014, invited by the editors
Patents
- E.T. Ahrens and
J.M. Janjic “Compositions and methods for
producing emulsions for nuclear magnetic resonance techniques and other
applications” 2016, US Patent 9,352,057, Assignee Celsense Inc.
- J.M. Janjic andE.T. Ahrens
“Compositions and methods for producing cellular labels for nuclear magnetic
resonance techniques” 2012, US Patent 8,227,610, Assignee Carnegie Mellon
University