PUBLICATIONS

  1. E. Lambert, V. Gorantla, J.M. Janjic* “Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine” Nanomedicine 2019, accepted : Part of Special Issue “Nanomedicine in  Organ  Transplantation  and  Regenerative Surgery –Advances,  Applications,  and Future Directions” Nanomedicine, November, 2019, Co-Edited by. V.S. Gorantla and J.M. Janjic
  2. M Saleem, B Deal, E. Nehl, JM Janjic, JA Pollock* “Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polaritry and mast cell activation.” Acta Neuropathol Commun. 2019. 7, Article number: 108
  3. M. Herneisey, E.Lambert, A. Kachel, E. Shychuck, J. K. Drennen III  and J.M. Janjic*Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale UpMolecules 2019, 24(11), 2066; https://doi.org/10.3390/molecules24112066
  4. M Saleem, AM Stevens, B Deal, L Liu, J Janjic, JA Pollock* “A New Best Practice for Validating Tail Vein Injections in Rat with Near-infrared-Labeled Agents.” Journal of visualized experiments: JoVE 2019 (146), e59295, doi:10.3791/59295
  5. J. M. JanjicInflammation Targeted Nanomedicine: A perspective on the promise and potential of biomedical technologies for pain diagnosis and management.” (Invited Article) Practical Pain Management 2019, Vol (19), Issue 1, pages: 33-35
  6. E. Lambert, J.M. Janjic* “Multiple Linear Regression Applied to Predicting Droplet Size of Complex Perfluorocarbon Nanoemulsions for Biomedical Applications” Pharmaceutical Development and Technology 2019, 24, 700-710
  7. M. Herneisey, L. Liu, E. Lambert, N. Schmitz, S. Loftus, and J.M. Janjic* Development of Theranostic Perfluorocarbon Nanoemulsions as a Model Non-Opioid Pain Nanomedicine Using a Quality by Design (QbD) Approach AAPS PharmSciTech 2019, 20: 65. https://doi.org/10.1208/s12249-018-1287-6
  8. J. M. Janjic* and V.S. Gorantla* “Novel Nanoimaging Strategies for Noninvasive Graft Monitoring in Vascularized Composite Allotransplantation” invited commentary, Current Transplantation Reports 2018, 5 (4), 369-372 https://doi.org/10.1007/s40472-018-0221-x 
  9. J. M. Janjic*, K. Vasudeva, M. Saleem, L. Liu, S.K. Patel, A. Stevens, J.A. Pollock* “Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in Rat” Journal of Neuroimmunology 2018,http://www.jni-journal.com/article/S0165-5728(18)30012-2/fulltext (The first Theranostic Pain Nanomedicine)
  10. J. M. Janjic* and V. Gorantla “Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind”, Proc. SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, 1050803 (20 February 2018); doi: 10.1117/12.2289288; https://doi.org/10.1117/12.2289288
  11. J. M. Janjic* and V. Gorantla “Peripheral Nerve Nano-Imaging: Monitoring Treatment and Regeneration” 2017, AAPS J. Sep;19(5), 1304-1316 (invited review)
  12. Herneisey, M., Williams, J., Mirtic, J., Liu, L., Potdar, S., Bagia, C., Cavanaugh, J.E., Janjic, J.M.* Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents Therapeutic Delivery 2016, 7 (12), 795-808
  13. BJ Kolber, JM Janjic, JA Pollock, KJ Tidgewell Summer undergraduate research: A new pipeline for pain clinical practice and research BMC Medical Education 2016 (1), 16:135 DOI: 10.1186/s12909-016-0648-7
  14. Janjic, J.M.*, Berlec, A., Bagia, C., Liu, L.S., Jeric, I., Gach, M., Janjic, B.M., Strukelj, B.NIR and MR imaging supported hydrogel based delivery system for anti-TNF alpha probiotic therapy of IBD (2016) Progress in Biomedical Optics and Imaging – Proceedings of SPIE, 9723, art. no. 972309
  15. Liu, L., Bagia,C., Janjic, J.M.* “The First Scale up Production of Theranostic Nanoemulsions” Bioresearch Open Access 2015, 4(1): 218-228. (Invited Paper)
  16. Patel, S.K., Beaino, W., Anderson, C.J., Janjic, J.M.* Theranostic Nanoemulsions for Macrophage COX-2 Inhibition in a Murine Inflammation Model Clinical Immunology 2015, 160, 59-70.
  17. S.K. Patel and J.M. Janjic* “Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory DiseasesTheranostics 2015,(2), 150
  18. Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic, J.M., Pollock, J.A.* “In Vivo and Systems Biology Studies Implicate IL-18 as a Central Mediator in Chronic Pain” Journal of Neuroimmunology 2015, 283, 43-49
  19. Wen, Y.,  Liu, W., Bagia,  C.,  Zhang, S., Bai,  M.,  Janjic, J.M.,  Giannoukakis, N., Gawalt, E. S., Meng, W.S.* “Antibody-Functionalized Peptidic Membranes for Neutralization of Allogeneic Skin Antigen-Presenting Cells” Acta Biomaterialia 2014, 10 (11), 4759-4767
  20. Jia, N., Zhang, S., Shao, P., Bagia, C., Janjic, J.M., Ding, Y. and Bai, M.* “Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth.” Molecular Pharmaceutics 2014, 11 (6), 1919–1929
  21. Janjic, J.M.*, Shao, P., Zhang, S., Yang, X., Patel, S.K., Bai, M.* “Perfluorocarbon nanoemulsions with fluorescent, colloidal and magnetic properties” Biomaterials 2014, 35 (18), 4958-4968
  22. Mountain, G.A., Jelier, B.J.,  Bagia, C., Friesen, C.M.,  Janjic, J.M. * “Design and formulation of nanoemulsions using 2-(poly (hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro (polyethylene glycol dimethyl ether)”Journal of Fluorine Chemistry 2014, 162, 38–44
  23. K. Vasudeva, K. Andersen, B. Zeyzus-Johns, T.K. Hitchens, S.K. Patel, A. Balducci, J.M. Janjic, J. A. Pollock* “Imaging Neuroinflammation In Vivo in a Neuropathic Pain Rat Model with Near-Infrared Fluorescence and 19F Magnetic Resonance” PloS one 2014, 9 (2), e90589
  24. M.J. Patrick¥, J.M. Janjic¥, H. Teng, M.R. O’Hear, C.W. Brown, J.A. Stokum,  B.F. Schmidt, E.T. Ahrens*, A.S. Waggoner “Intracellular pH measurements using perfluorocarbon nanoemulsions” Journal of the American Chemical Society 2013, 135 (49), 18445-18457. (¥Co-first authors)
  25. S.K. Patel, J. Williams, J.M. Janjic* “Cell labeling for 19F MRI: New and Improved Approach to Perfluorocarbon Nanoemulsion Design” Biosensors 2013, 3(3), 341-359 (open access)
  26. S.K. Patel, M.J. Patrick, J.A. Pollock, J.M. Janjic* “Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemulsions” Journal of Biomedical Optics 2013, 18 (10), 101312,
  27. J.M. Janjic*, S.K. Patel, M.J. Patrick, J.A. Pollock, E. DiVito, M. Cascio “Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics”  (Invited Paper) Progress in Biomedical Optics and Imaging – Proceedings of SPIE 2013, 8596, art. no. 85960L 
  28. S.K. Patel, Y. Zhang, J.A. Pollock, J.M. Janjic* “Cyclooxygenase-2 Inhibiting Perfluoropoly (ethylene glycol) ether Theranostic Nanoemulsions – In Vitro Study” PloS one 2013, 8(2):e55802.
  29. A. Balducci, Y. Wen, Y. Zhang,  B.M. Helfer, T.K. Hitchens, W.S. Meng, A.K. Wesa, J.M. Janjic*, “A novel probe for the non-invasive detection of tumor-associated inflammation” Oncoimmunology 2013, 2 (2), e23034
  30. C.E. O’Hanlon, K.G. Amede, M.R. O’Hear, J.M. Janjic* “NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging” Journal of Fluorine Chemistry 2012, 137, 27–33
  31. T.K. Hitchens, Q. Ye, D.F. Eytan, J.M. Janjic, E.T. Ahrens,  C. Ho “19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells” Magnetic Resonance in Medicine 2011, 65, 1144-1153
  32. D.K.K. Kadayakkara, J.M. Janjic, L.K. Pusateri, W.B. Young, E.T. Ahrens “In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI” Magnetic Resonance in Medicine 2010, 64,1252-1259    
  33. B. Helfer, A. Balducci, A. Nelson, J.M. Janjic, R.R. Gil, P. Kalinski, J. M. de Vries, E.T. Ahrens, R. Mailliard, “Functional assessment of human dendritic cells labeled for in vivo 19F MRI cell tracking” Cytotherapy 2010, 12, 238-250.
  34. D.K.K. Kadayakkara, P. Beatty, J.M. Janjic, M. Turner, E. Ahrens, O. Finn “Inflammation driven overexpression of the hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and pancreatitis” Pancreas 2010, 39, 510-515
  35. M. Srinivas, M.S. Turner, J.M. Janjic, P.A. Morel, D.H. Laidlaw, E.T. Ahrens “In vivo cytometry of antigen specific T-cells using 19F MRI” Magnetic Resonance in Medicine 2009, 62, 747-753
  36. J.M. Janjic, E.T. Ahrens “Fluorine-containing nanospheres for MRI” Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Sept./Oct. 2009, 1, 492-501, invited by editors
  37. J.M. Janjic, M. Srinivas, D.K.K. Kadayakkara, E.T. Ahrens “Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection”, Journal of American Chemical Society 2008, 130, 2832-2413. (highly cited paper, cited >200 times)
  38. Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day, B.W. “Biphenyl C-cyclopropylalkylamides as new scaffolds for targeting estrogen receptor β” Bioorganic Medicinal Chemistry Letters 2009, 19, 2404-2408.
  39. Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day, B.W.; Xie, W. “New Opportunities for pregnane X receptor (PXR) targeting in drug development. Lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues” Mini Reviews Medicinal Chemistry 2007, 7, 617-625
  40. Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer, P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day, B.W. “Microwave-Assisted “Libraries from Libraries” Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides,” Journal of Combinatorial Chemistry 2005, 7, 322-330.
  41. Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs, R.B.; Kroboth, P.D.; Smith, R.B.; “GEAR-UP (Graduate Education And Research at the University of Pittsburgh), A Program for Educating Students about Pharmaceutical Research,” American Journal of Pharmaceutical Education 2005, 69, 91-97.  (co-wrote the paper, co-designed the study, served on the organizational committee of the program 2001-2004)
  42. Janjic, J.M.; Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S. ; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. “New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides,” Bioorganic and Medicinal Chemistry 2005, 13, 157-164.
  43. Wipf, P.; Janjic, J.M.; Stephenson, C.R. “Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence,” Organic and Biomolecular Chemistry 2004, 2, 443-445. 
  44. Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside, T.L.; Storkus, W.J.; Vujanovic, N.L. “Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand,” Journal of Immunology 2002, 168, 1831-1839.

Book Chapters

  1. W. Meng* and J.M. Janjic Book chapter “Principles of Nanomedicine ” in book titled: Nanomedicine for Inflammatory Diseases edited by Lara Sheherazade Milane and Mansoor M. Amiji, invited by the editors, 2017 Nanomedicine for Inflammatory Diseases, 39-66
  2. J.M. Janjic* and S.K. Patel “Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist’s Perspective” book chapter in book titled: Fluorine Magnetic Resonance Imaging Edited by Ulrich Flögel & Eric Ahrens, invited by the editors, Pan Stanford Publishing Pte. Ltd. 2016 DOI: 10.1201/9781315364605-15
  3. J.M. Janjic*, S.K. Patel, C. Bagia “Utilization of Near-Infrared Fluorescent Imaging for Pharmaceutically Relevant Applications” Book chapter in 2016 In Vivo Fluorescence Imaging: Methods and Protocols, 97-108, edited by Mingfeng Bai, PhD, Springer New York 2016 DOI: 10.1007/978-1-4939-3721-9_10, invited by the editors
  4. J.M. Janjic and M. Bai “Design and Development of Theranostic Nanomedicines” Chapter in: Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, Edited by Mikhail Berezin, John Wiley & Sons, Inc; 2014, invited by the editors

Patents

  1. E.T. Ahrens and J.M. Janjic “Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications” 2016, US Patent 9,352,057, Assignee Celsense Inc.
  2. J.M. Janjic andE.T. Ahrens  “Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques” 2012, US Patent 8,227,610, Assignee Carnegie Mellon University